Diminished adult neurogenesis in the marmoset brain precedes old age

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Diminished adult neurogenesis in the marmoset brain precedes old age.

With aging there is a decline in the number of newly generated neurons in the dentate gyrus of the hippocampus. In rodents and tree shrews, this age-related decrease in neurogenesis is evident long before the animals become aged. No previous studies have investigated whether primates exhibit a similar decline in hippocampal neurogenesis with aging. To investigate this possibility, young to midd...

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Neurogenesis in the adult brain.

A milestone is marked in our understanding of the brain with the recent acceptance, contrary to early dogma, that the adult nervous system can generate new neurons. One could wonder how this dogma originally came about, particularly because all organisms have some cells that continue to divide, adding to the size of the organism and repairing damage. All mammals have replicat-ing cells in many ...

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Neurogenesis in Adult Brain

The idea that the adult brain retains the capacity to generate new neurons has been proposed several times over the last 40 years, and in each case both conceptual and technical constraints have led to resistance. Joseph Altman first reported that some dividing cells in the adult brain survived and differentiated into cells with morphology similar to neurons using tritiated thymidine autoradiog...

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Hippocampal neurogenesis in adult Old World primates.

The production of new hippocampal neurons in adulthood has been well documented in rodents. Recent studies have extended these findings to other mammalian species, such as tree shrews and marmoset monkeys. However, hippocampal neurogenesis has not been demonstrated in adult Old World primates. To investigate this possibility, we injected 11 adult Old World monkeys of different ages (5-23 years)...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2007

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.0708228104